LuPone made her Penny Dreadful debut in the second season of the John Logan series, playing the Cut-Wife, who was eventually burned alive. She has returned as a new character, Florence Seward, which LuPone says is a “terrific part and I would have been a fool to turn it down. She’s a tough New Yorker who had some trauma in her life back in America and was acquitted and vindicated. Her back story is mysterious but it’s clear she escaped to London for a new beginning. Seward could also be in tune with her ancestral powers, though she claims she doesn’t know or care about her connection to the Cut-Wife.”

The Broadway favorite will also be seen in the new musical War Paint, which casts the singing actress as Helena Rubinstein opposite the Elizabeth Arden of Christine Ebersole. About the musical, which opens at Chicago's Goodman Theatre July 18, LuPone says, "I’ve been with this show forever. It’ll be four years by the time it hits Broadway. The music and lyrics are by Scott Frankel and Michael Korie, the gentlemen who brought us Grey Gardens. Doug Wright wrote the book, which is based on the rivalry between Helena Rubinstein and Elizabeth Arden, two titans of the cosmetic industry. I love it a lot. We’ll see what happens."

And, LuPone also explains how she would like to conclude her award-winning entertainment career: “It took a long time for people in the business to accept the fact that I could do television. But that’s true with a lot of New York actresses. They thought we were too big for the camera. That’s all changed. I’m all about television now. In fact, I want to end my career in a big fat hit situation comedy. [Laughs.] That’s all I ask.”