Tony winner Doug Hughes will direct the April 27 performance at the Samuel J. Friedman Theatre. Show time is 7 PM.

Joining LuPone and Cannavale will be Cristin Milioti, George Morfogen, Brenda Wehle, Tina Benko, Jennifer Regan, Patch Darragh, Stephanie DiMaggio, Peter Mark Kendall, Angela Pierce, Robin Galloway, Johann Carlo, Mary Lou Rosato, Pamela Nyberg, Christian Conn, Eliza Baldi and Leigh Wade.

"The Rose Tattoo is the story of Serafina, a Louisiana widow who withdraws from the world after her husband's death and expects her daughter to do the same,” said Margot Harley, producer of The Acting Company. “One day, a man resembling her late husband comes into her life and unlocks her fiery passion, wit, anger and pride.”

“This is a play of power, humanity and soaring emotion,” added LuPone, a founding alumna of The Acting Company.

Williams' drama, written in 1951 between Streetcar Named Desire and Cat on a Hot Tin Roof, originally starred Maureen Stapleton and Eli Wallach. It has been revived twice on Broadway, in 1966 with Stapleton and Harry Guardino, and 1995 with Mercedes Ruehl and Anthony LaPaglia.

Samuel J. Friedman Theatre is located at 261 West 47th Street. For tickets, priced $100-$250, visit Telecharge.com or call (212) 239-6200 or (800) 447-7400. For benefit tickets, which include dinner with the cast, call (212) 258-3111.

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Founded in 1972 by John Houseman and Margot Harley, The Acting Company has toured 139 productions to 48 states and 10 foreign countries earning a Tony for Excellence in Theater, Obies, Audelcos and Los Angeles Critics Circle Awards.