Hardin had to "return to Los Angeles to deal with family issues and therefore had to withdraw from the production," according to a March 11 press statement.
Directed by John Tillinger, the comedy will officially open April 26. The cast also features Ben Daniels, Adam James and Jennifer Tilly with Spencer Kayden and David Aron Damane.
Kalember previously played the role of Jacqueline in a Chicago production of Don’t Dress for Dinner, also directed by Tillinger.
Kalember was last seen on Broadway in Losing Louie. She appeared in two Larry Shue plays in New York City: Broadway's The Nerd and Off-Broadway's The Foreigner.
Don’t Dress for Dinner, which is scheduled to run through June 17, is a Roundabout Theatre Company production, in association with Damian Arnold.