Emmy Award nominee Evelyn Rudie ("Eloise") will direct the production, which is scheduled to begin previews Off-Broadway Nov. 14 at St. Luke’s Theatre (308 West 46th Street, between 8th and 9th Avenues). Opening night is Dec. 9.

McArdle will be joined onstage by Kip Gilman.

"Two strangers, a psychologist (Andrea McArdle) and an unemployed ad man (Kip Gilman) find themselves alone on a San Francisco commuter train at 4 AM, each doing their New York Times crossword puzzles," according to press notes. "But before their crosswords are solved, they find that they may have solved the puzzles of their own lives."

The 90-minute show will be presented Wednesday and Saturday evenings at 8 PM with Sunday matinees at 2 PM.

Tickets, beginning at $39.50, are available at Telecharge.com or by calling (212) 239-6200. For more information visit 2acrosstheplay.com.