Directed by Scott Weinstein, the hit musical will play the 100-seat Theater Wit beginning Oct. 18. Elizabeth Doran is the musical director for the production, which will continue through Dec. 7.
Casting will be announced at a later date.
The Chicago staging will feature a version of the musical that has been reworked to suit more intimate spaces. Orchestrations are by Ian Weinberger.
Titanic won 1997 Tony Awards for Best Book of a Musical (Peter Stone), Best Musical, Best Orchestrations (Jonathan Tunick), Best Score (Maury Yeston) and Best Lighting Design (Stewart Laing).
Tickets for the limited engagement will go on sale Aug. 1 by visiting theaterwit.org.