Weigle has appeared as a guest conductor with Cincinnati Opera, Dresden State Opera, Opera Australia, the Vienna State Opera, the Metropolitan Opera, and elsewhere. In 2003, he was named conductor of the year by Opernwelt magazine for a Frankfurt Opera production of Strauss's Die Frau ohne Schatten.
Carignani announced in June that he would he would leave Frankfurt Opera in 2008, surprising local observers and city officials. Asked whether backstage intrigue had led to his resignation, he would say only that "there is also intrigue at supermarkets, banks, and stock markets."
Previous conductors at Frankfurt Opera include Georg Solti, Christoph von Dohnšnyi, and Michael Gielen.