Joining Michele (Spring Awakening, Fiddler on the Roof) are Joe Manganiello ("True Blood," "How I Met Your Mother"), Academy Award nominee Abigail Breslin ("Little Miss Sunshine," The Miracle Worker) and Keke Palmer ("Akeela and the Bee," Cinderella).
Pop star Ariana Grande, who appeared in Jason Robert Brown's 13 will play a recurring role in the series, which will also feature horror movie veterans Jamie Lee Curtis ("Halloween") and Emma Roberts ("Scream 4").
"Scream Queens" will begin with murders taking place on a college campus.
Fifteen one-hour episodes of the anthology series, which will premiere in fall 2015, have been ordered for 20th Century Fox TV.