Directed by Charlotte Moore, the production plays through Dec. 29 in The Irish Repertory Theatre's W. Scott McLucas Studio Theatre.
Along with McGillin (Anything Goes, The Phantom of the Opera), the cast includes Haley Bond, Rory Duffy, Kristin Griffith, Ian Holcomb and Peter Maloney.
It's a Wonderful Life is adapted by Anthony E. Palermo from the screenplay by Francis Goodrich, Albert Hackett, Frank Capra and Jo Swerling.
"Set in a radio station in the 1940's, with a busy live sound FX artist and six actors playing 25 characters, this beloved, poignant Christmas classic comes vividly to life... " press notes state. "Christmas Eve in America, 1946. George Bailey, the nicest guy in town, is in a terrible predicament. Perched precariously on the Bedford Fall Bridge, on the brink of suicide, George encounters Clarence, his Guardian Angel, who has not yet earned his wings. Clarence takes George in hand and shows him what the small town of Bedford Falls would have been if he had never been born."
It's a Wonderful Life features set design by James Morgan, costume design by David Toser, lighting design by Michael O'Connor and live sound design by Zachary Williamson. The production stage manager is Michael Palmer.
For tickets and information, call (212) 727-2737 or visit irishrep.org.