The drag icon is unveiling a supervillain alter ego in the upcoming show set to visit 33 cities across the U.S.
He will succeed Arthur de Bok in May.
Tysen will write lyrics to the music of Jekyll & Hyde composer Frank Wildhorn.
Nygel D. Robinson and Brian Quijada star in the live-looping musical, which premiered via Audible Theater last year.
The evening celebrating the 80th birthday of the entertainment icon will feature a a seven-piece band led by music director Dan Pardo.
Theater Breaking Through Barriers will present the original short works at Theatre Row.
Writer John Caird will co-direct the reimagined production of the Broadway musical with Megan McGinnis.
Chloe Claudel will direct the newest work by the Grief Camp playwright.
The dance company led by Broadway choreographer Chase Brock will play a strictly limited engagement at A.R.T./New York Theatres.